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Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages.


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Title: Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages.
Authors: Honda, Shoko / Saito, Mariko / Dimaano, Efren M / Morales, Philip A / Alonzo, Maria T G / Suarez, Lady-Anne C / Koike, Natsuki / Inoue, Shingo / Kumatori, Atsushi / Matias, Ronald R / Natividad, Filipinas F / Oishi, Kazunori
Issue Date: May-2009
Publisher: The American Society of Tropical Medicine and Hygiene
Citation: The American journal of tropical medicine and hygiene, 80(5), pp.841-845; 2009
Abstract: The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P = 0.011) and the levels of PAIgG (P = 0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the levels of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.
URI: http://hdl.handle.net/10069/23207
ISSN: 00029637
PubMed ID: 19407135
Rights: Copyright © 2009 by The American Society of Tropical Medicine and Hygiene
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23207

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