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Roles of the Valine Clusters in Domain 3 of the Hemolytic Lectin CEL-III in Its Oligomerization and Hemolytic Abilities


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Title: Roles of the Valine Clusters in Domain 3 of the Hemolytic Lectin CEL-III in Its Oligomerization and Hemolytic Abilities
Authors: Hisamatsu, Keigo / Unno, Hideaki / Goda, Shuichiro / Hatakeyama, Tomomitsu
Issue Date: 1-Apr-2009
Publisher: Bentham Science Publishers
Citation: Protein and Peptide Letters, 16(4), pp.411-414; 2009
Abstract: The hemolytic lectin CEL-III and its site-directed mutants were expressed in Escherichia coli cells. Replacement of the valine clusters in domain 3 with alanine residues led to increased self-oligomerization in solution and higher hemolytic activity. The results suggest the involvement of these valine clusters in CEL-III oligomerization and hemolytic activity.
Keywords: Cucumaria echinata / Hemolysin / Lectin / Oligomerization / Site-directed mutagenesis
URI: http://hdl.handle.net/10069/23319
ISSN: 09298665
DOI: 10.2174/092986609787848054
Rights: © 2009 Bentham Science Publishers Ltd.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23319

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