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Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation. A prospective randomized study.


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Title: Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation. A prospective randomized study.
Authors: Eguchi, Susumu / Takatsuki, Mitsuhisa / Hidaka, Masaaki / Soyama, Akihiko / Ichikawa, Tatsuki / Kanematsu, Takashi
Issue Date: Apr-2011
Publisher: Elsevier Inc.
Citation: American Journal of Surgery, 201(4), pp.498-502; 2011
Abstract: BACKGROUND: Although the effect of synbiotic therapy using prebiotics and probiotics has been reported in hepatobiliary surgery, there are no reports of the effect on elective living-donor liver transplantation (LDLT). METHODS: Fifty adult patients undergoing LDLT between September 2005 and June 2009 were randomized into a group receiving 2 days of preoperative and 2 weeks of postoperative synbiotic therapy (Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides [the BLO group]) and a group without synbiotic therapy (the control group). Postoperative infectious complications were recorded as well as fecal microflora before and after LDLT in each group. RESULTS: Only 1 systemic infection occurred in the BLO group (4%), whereas the control group showed 6 infectious complications (24%), with 3 cases of sepsis and 3 urinary tract infections with Enterococcus spp (P = .033 vs BLO group). No other type of complication showed any difference between the groups. CONCLUSIONS: Infectious complications after elective LDLT significantly decreased with the perioperative administration of synbiotic therapy.
Keywords: Infectious complication / Living donor liver transplantation / Synbiotic therapy
URI: http://hdl.handle.net/10069/23427
ISSN: 00029610
DOI: 10.1016/j.amjsurg.2010.02.013
PubMed ID: 20619394
Rights: Copyright © 2010 Elsevier Inc. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23427

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