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Protective effect of Sanguisorbae Radix against apoptosis and function of renal tissues subjected to ischemia-reperfusion


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Title: Protective effect of Sanguisorbae Radix against apoptosis and function of renal tissues subjected to ischemia-reperfusion
Authors: Chen, Cui Ping / Yokozawa, Takako / Tanaka, Takashi
Issue Date: 25-Aug-1999
Publisher: Medical and Pharmaceutical Society for WAKAN-YAKU / 和漢医薬学会
Citation: Journal of traditional medicines, 16(3), pp.97-101; 1999
Abstract: DNA ladders were detected by gel electrophoresis of DNA obtained from rat kidney subjected to 60 min of ischemia followed by 24 h of reperfusion, indicating the involvement of apoptosis in ischemia-reperfusion injury. This ladder formation was significantly inhibited by oral administration of Sanguisorbae Radix extract to rats for 30 days prior to ischemia-reperfusion. In addition, blood levels of urea nitrogen and creatinine, two parameters of renal function, were markedly lower in the Sanguisorbae Radix-treated animals than in the untreated controls. These results suggest that Sanguisorbae Radix has potential for attenuating renal injury and accelerating the recovery of renal function after ischemia-reperfusion injury, which might involve inhibition of apoptosis. / 60分間虚血後,24時間再灌流したラット腎のDNAにラダーが出現し,腎虚血一再灌流障害にアポトーシスが関与していることが示唆された。このようなDNAの断片化は,地楡エキスを前もって30日間経口投与した場合,有意に抑制され,腎機能の指標の血中尿素窒素とクレアチニンレベルも地楡エキス処理群で著しく低下していた。このことから,地楡はアポトーシスが関与した腎虚血一再灌流障害を軽滅して,腎機能の回復をはかっているものと推測された。
Keywords: Sanguisorbae Radix / ischemia-reperfusion / apoptosis / DNA fragmentation / rental function / kidney
URI: http://hdl.handle.net/10069/23538
ISSN: 13406302
Relational Links: http://ci.nii.ac.jp/naid/110002536553/
Rights: Medical and Pharmaceutical Society for WAKAN-YAKU / 本文データは学協会の許諾に基づきCiNiiから複製したものである
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23538

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