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高尿酸血症の持続により持続性の多発関節炎を呈した慢性結節性痛風の一例


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Title: 高尿酸血症の持続により持続性の多発関節炎を呈した慢性結節性痛風の一例
Other Titles: A case of chronic tophaceous with a continuous polyarthritis and joint deformity caused by uncontrolled hyperuricemia
Authors: 川尻, 真也 / 川上, 純 / 岩本, 直樹 / 藤川, 敬太 / 荒牧, 俊幸 / 一瀬, 邦弘 / 蒲池, 誠 / 玉井, 慎美 / 中村, 英樹 / 井田, 弘明 / 折口, 智樹 / 江口, 勝美
Authors (alternative): Kawashiri, Shinya / Kawakami, Atsushi / Iwamoto, Naoki / Fujikawa, Keita / Aramaki, Toshiyuki / Ichinose, Kunihiro / Kamachi, Makoto / Tamai, Mami / Nakamura, Hideki / Ida, Hiroaki / Origuchi, Tomoki / Eguchi, Katsumi
Issue Date: Jun-2008
Publisher: 日本臨床免疫学会 / The Japan Society for Clinical Immunology
Citation: 日本臨床免疫学会会誌, 31(3), pp.190-194; 2008
Abstract: 症例は56歳,女性.主訴は多発関節痛.1999年に拇趾MTP関節の痛風発作を発症した.その後,痛風発作を繰り返すもコルヒチン内服にて症状は軽快していた.しかし,2006年頃より関節痛は全身の多関節におよび,持続性となった.2007年4月,多発関節炎の精査加療目的にて当科紹介入院となった.入院時,著明な高尿酸血症を認めた.入院中,関節炎発作による全身の関節痛および高熱を認めた.関節液所見にて白血球に貪食された尿酸ナトリウム針状結晶を認め,痛風と診断した.デキサメタゾン4 mg筋注およびコルヒチン投与により症状は改善した. / A 56-year-old woman was admitted to our hospital in April 2007 due to a history of polyarthralgia. In 1999, She had been diagnosed as having gout by monoarthritis of the first metatarsophalangeal joint. She was treated with only cholchine. Subsequently she repeatedly got acute attack once a year. In 2006, episodic monoarthritis became to be continuous polyarthritis. Laboratory examination at admission showed remarkable hyperuricemia. At 3 day after hospitalization, she experienced acute attack and high fever. Diagnosis of chronic gout was confirmed by the identification of monosodium urate crystals in the synovial fluid. Her symptom improved by a treatment with dexamethasone 4 mg/day i.m. and cholchine, and did not experience acute attack for 5 months. We suggest that prophylactic administration of cholchine is beneficial in refractory chronic gout patient.
Keywords: chronic tophaceous gout / polyarthritis / hyperuricemia / cholchicine
URI: http://hdl.handle.net/10069/23600
ISSN: 09114300
DOI: 10.2177/jsci.31.190
PubMed ID: 18587231
Rights: Copyright (c) 2008 日本臨床免疫学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23600

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