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脳梗塞に関する実験的研究 : 血管鋳型走査電顕法を中心に


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タイトル: 脳梗塞に関する実験的研究 : 血管鋳型走査電顕法を中心に
その他のタイトル: Experimental Cerebral Infarction in the Dog : Scanning Electron Microscopy with Vascular Endocasts of the Microvessels in the Ischemic Brain
著者: 堤, 健二
著者(別表記) : Tsutsumi, Kenji
発行日: 1986年 8月15日
出版者: 日本脳神経外科学会 / The Japan Neurosurgical Society
引用: Neurologia medico-chirurgica, 26(8), pp.595-600; 1986
抄録: Large-sized infarctions of the cerebral hemisphere (LSICH) were expreimentally induced in 17 dogs by injecting two silicone cylinders through the right cervical internal carotid artery. The LSICH models were perfused with heparinized saline and fixed with 1.5% glutaraldehyde solution through the contralateral carotid artery. Then 24 hours after the embolization, Mercox(R) CL-2B and CL-2R were injected manually. The brains were immediately removed, and specimens were obtained from the basal ganglia and the ectosylvian cortex. Disruptions of the degenerated arterioles with numerous erythrocytes and Mercox were observed in the area of massive hemorrhagic infarct in the basal ganglia. On the other hand, disruptions of degenerated venules with a few erythrocytes and Mercox around the vessels were observed in the petechial hemorrhagic infarct in the corticomedullary junction area. Dilatation of the pervascular space of the microvessels and vacuolation of the neuropiles were related to the severity of the vasogenic edema. Microvessels were narrowed and decreased in flexibility in severe vasogenic edema. Some arterioles ran parallel and branched convergently. It was suggested that changes in the microvascular structure were caused by disturbance of the autoregulation of the cerebral microcirculation.
キーワード: vessels / experiment / hemorrhagic inforction / electron microscopy
URI: http://hdl.handle.net/10069/23674
ISSN: 04708105
関連リンク : http://ci.nii.ac.jp/naid/110002279701/
権利: 日本脳神経外科学会 / 本文データは学協会の許諾に基づきCiNiiから複製したものである
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/23674

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