DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 230 先導生命科学研究支援センター > 230 学術雑誌論文 >

A parenteral DNA vaccine protects against pneumonic plague.

ファイル 記述 サイズフォーマット
Vaccine28_3219.pdf791.01 kBAdobe PDF本文ファイル

タイトル: A parenteral DNA vaccine protects against pneumonic plague.
著者: Yamanaka, Hitoki / Hoyt, Teri / Yang, Xinghong / Bowen, Richard / Golden, Sarah / Crist, Kathryn / Becker, Todd / Maddaloni, Massimo / Pascual, David W
発行日: 2010年 4月19日
出版者: Elsevier Ltd.
引用: Vaccine, 28(18), pp.3219-3230; 2010
抄録: The chemokine, lymphotactin (LTN), was tested as a molecular adjuvant using bicistronic DNA vaccines encoding the protective Yersinia capsular (F1) antigen and virulence antigen (V-Ag) as a F1-V fusion protein. The LTN-encoding F1-V or V-Ag vaccines were given by the intranasal (i.n.) or intramuscular (i.m.) routes, and although serum IgG and mucosal IgA antibodies (Abs) were induced, F1-Ag boosts were required for robust anti-F1-Ag Abs. Optimal efficacy against pneumonic plague was obtained in mice i.m.-, not i.n.-immunized with these DNA vaccines. These vaccines stimulated elevated Ag-specific Ab-forming cells and mixed Th cell responses, with Th17 cells markedly enhanced by i.m. immunization. These results show that LTN can be used as a molecular adjuvant to enhance protective immunity against plague.
キーワード: IgA / Lymphotactin / Mucosal / Pneumonic plague / Vaccines
URI: http://hdl.handle.net/10069/23688
ISSN: 0264410X
DOI: 10.1016/j.vaccine.2010.02.022
PubMed ID: 20197132
権利: Copyright © 2010 Elsevier Ltd All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:230 学術雑誌論文

引用URI : http://hdl.handle.net/10069/23688



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace