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Proliferating Cell Nuclear Antigen (Pcna/Cyclin): Review and Some New Findings (Histo- and Cytochemistry in Tissue Culture)


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Title: Proliferating Cell Nuclear Antigen (Pcna/Cyclin): Review and Some New Findings (<Symposium>Histo- and Cytochemistry in Tissue Culture)
Authors: Nakane, Paul K. / Moriuchi, Tetsuya / Koji, Takehiko / Taniguchi, Yasushi / Izumi, Shin-Ichi / Hui, Li
Issue Date: 1989
Publisher: The Japan Society of Histochemistry and Cytochemistry / 日本組織細胞化学会
Citation: Acta Histochemica et Cytochemica, 22(1), pp.105-116; 1989
Abstract: PCNA/cyclin was originally described in proliferating mammalian cells as a nuclear protein with an apparent molecular weight of 33, 000-36, 000, and recently found to be a DNA polymerase-delta auxiliary protein. When the cDNA for PCNA/cyclin was cloned and analyzed, it was found that the protein consisted of 261 amino acids with a calculated molecular weight of 28, 700 and the amino acid sequence was well conserved during evolution both in animal and plant kingdoms. The highly homologous nature of PCNA/cyclin suggests that the protein plays an essential role in DNA replication in eukaryotes.
URI: http://hdl.handle.net/10069/23707
ISSN: 00445991
Rights: Copyright ©1989 By the Japan Society of Histochemistry and Cytochemistry
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23707

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