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Primary Ciliary Dyskinesia that Responded to Long-Term, Low-Dose Clarithromycin


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Title: Primary Ciliary Dyskinesia that Responded to Long-Term, Low-Dose Clarithromycin
Authors: Yoshioka, Daisuke / Sakamoto, Noriho / Ishimatsu, Yuji / Kakugawa, Tomoyuki / Ishii, Hiroshi / Mukae, Hiroshi / Kadota, Jun-ichi / Kohno, Shigeru
Issue Date: 2010
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 49(14), pp.1437-1440; 2010
Abstract: A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.
Keywords: Clarithromycin / Immotile cilia syndrome / Macrolide / Primary ciliary dyskinesia
URI: http://hdl.handle.net/10069/23877
ISSN: 09182918
DOI: 10.2169/internalmedicine.49.3453
Rights: Copyright (c) 2010 by The Japanese Society of Internal Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23877

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