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Liver architecture, cell function, and disease.

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タイトル: Liver architecture, cell function, and disease.
著者: Ishibashi, Hiromi / Nakamura, Minoru / Komori, Atsumasa / Migita, Kiyoshi / Shimoda, Shinji
発行日: 2009年 9月
出版者: Springer Berlin
引用: Seminars in immunopathology, 31(3), pp.399-409; 2009
抄録: The liver is an organ consisting of the largest reticulo-endothelial cell network in the body and playing an important role in host defense against invading microorganisms. The organ is comprised of parenchymal cells and many different types of non-parenchymal cells, all of which play a significant role. Even biliary epithelial cells are not only the target in autoimmune liver diseases but also have central role in orchestrating several immune cells involved in both innate and acquired immunity. Tissue damage caused by various agents results in inflammation, necrosis, fibrosis, and, eventually, distortion of normal hepatic architecture, cirrhosis, and functional deterioration.
キーワード: Innate immunity / Kupffer cells / Cytokine / Chemokine / Toll-like receptor
URI: http://hdl.handle.net/10069/24049
ISSN: 18632297
DOI: 10.1007/s00281-009-0155-6
PubMed ID: 19468732
権利: © Springer-Verlag 2009 / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24049



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