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Sarcoidosis in a Patient with Systemic Sclerosis and Primary Biliary Cirrhosis


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Title: Sarcoidosis in a Patient with Systemic Sclerosis and Primary Biliary Cirrhosis
Authors: Sakamoto, Noriho / Ishimatsu, Yuji / Kakugawa, Tomoyuki / Hara, Atsuko / Hara, Shintaro / Amenomori, Misato / Fujita, Hanako / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: 2010
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 49(15), pp.1609-1611; 2010
Abstract: A 73-year-old woman who had been diagnosed with systemic sclerosis was admitted for further examination of bilateral hilar lymphadenopathy. Sarcoidosis was confirmed based on elevated serum levels of angiotensin-converting enzyme, a high proportion of lymphocytes and a high CD4/CD8 ratio in bronchoalveolar lavage fluid, abnormal 67Gallium uptake in the mediastinum and noncaseating granulomas in skin biopsy specimens. In addition, high levels of antimitochondrial M2 antibodies and alkaline phosphatase indicated primary biliary cirrhosis (PBC). Here we describe a rare triplex of sarcoidosis, SSc and PBC. Although the etiology of this complex remains unknown, these three diseases might share some pathogenesis.
Keywords: CREST syndrome / Primary biliary cirrhosis / Sarcoidosis / Systemic sclerosis
URI: http://hdl.handle.net/10069/24058
ISSN: 09182918
DOI: 10.2169/internalmedicine.49.3457
Rights: © 2010 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24058

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