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早期関節炎の捉え方と病態解析の方向性


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Title: 早期関節炎の捉え方と病態解析の方向性
Other Titles: Classification of early arthritis patients and how to determine disease severity
Authors: 川上, 純 / 玉井, 慎美 / 江口, 勝美
Authors (alternative): Kawakami, Atsushi / Tamai, Mami / Eguchi, Katsumi
Issue Date: 28-Feb-2007
Publisher: 日本臨床免疫学会 / The Japan Society for Clinical Immunology
Citation: 日本臨床免疫学会会誌, 30(1), pp.37-40; 2007
Abstract: 近年の臨床研究で関節リウマチの予後は早期からの治療介入により改善し,かつ,生物学的製剤の早期治療では約半数の症例で臨床的寛解が得られることが明らかとなった.すなわち関節リウマチの早期診断および早期からの適切な治療法の選択は極めて重要である.私たちは早期関節炎の前向き症例対照研究により,初診時に抗CCP抗体およびMRIでの骨髄浮腫が陽性の早期関節炎は,高率に関節リウマチに進展することを明らかにした.これら臨床的評価に加え遺伝学的解析も含めた早期関節炎の層別化を試みており,これらのデータをもとに早期関節炎の捉え方と病態解析の方向性について述べる. / Recent clinical studies of rheumatoid arthritis reveal that therapeutic intervention early in rheumatoid arthritis leads to less joint damage, indicating the importance of early diagnosis of RA for improvement of prognosis. According to the data of our “Early Arthritis Prospective Cohort”, we have found that early arthritis patients, described as undifferentiated arthritis, progress to rheumatoid arthritis at high frequency if the patients positive with anti-cyclic citrullinated peptide antibody (anti-CCP antibody) and bone marrow edema at the entry. In addition, we are going to classify the pathologic status (disease severity) of early arthritis patients by serologic variables, radiographic findings and genetic analysis.
Keywords: rheumatoid arthritis / anti-CCP antibody / MRI / bone marrow edema / genetic analysis
URI: http://hdl.handle.net/10069/24072
ISSN: 09114300
DOI: 10.2177/jsci.30.37
Rights: Copyright (c) 2007 日本臨床免疫学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24072

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