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Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: A multicenter trial in Japan.


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タイトル: Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: A multicenter trial in Japan.
著者: Kohno, Shigeru / Izumikawa, Koichi / Ogawa, Kenji / Kurashima, Atsuyuki / Okimoto, Niro / Amitani, Ryoichi / Kakeya, Hiroshi / Niki, Yoshihito / Miyazaki, Yoshitsugu
発行日: 2010年11月
引用: The Journal of infection, 61(5), pp.410-418; 2010
抄録: Chronic pulmonary aspergillosis (CPA) is slowly progressive inflammatory pulmonary syndrome due to Aspergillus spp. The evidence regarding CPA treatment is limited. We conducted a randomized, multicenter, open-label trial comparing intravenous micafungin (MCFG) of 150-300 mg once daily with intravenous voriconazole (VRCZ) of 6 mg/kg twice on Day 1 followed by 4 mg/kg twice daily for the treatment of 107 in patients with CPA to compare the efficacy and safety of both drugs as initial treatment in Japan. Treatment effectiveness was defined by clinical, mycological, radiological and serological responses 2 weeks after the initial administration and at the end of therapy. The total of 50 and 47 patients were assigned to the MCFG and VRCZ groups, respectively. The difference in efficacy rates between MCFG and VRCZ was not significant, either after 2 weeks [68.0% vs. 58.7%; the absolute difference, 9.3% with a 95% confidence interval (CI), -9.97 to 28.58, P = 0.344] or at the end of therapy (60.0% vs. 53.2%; the absolute difference, 6.8% with a 95% CI, -12.92 to 26.54, P = 0.499). In the safety evaluation, fewer adverse events occurred in the MCFG than VRCZ group (26.4% vs. 61.1%, P = 0.0004). MCFG was as effective as VRCZ and significantly safer than as an initial treatment of CPA. (UMIN Clinical Trials Registry number, UMIN000001786.).
キーワード: Chronic pulmonary aspergillosis / Micafungin / Voriconazole
URI: http://hdl.handle.net/10069/24110
ISSN: 01634453
DOI: 10.1016/j.jinf.2010.08.005
PubMed ID: 20797407
権利: Copyright © 2010 The British Infection Society Published by Elsevier Ltd.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24110

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