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Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation.

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Title: Lack of Grafted Liver Rejuvenation in Adult-to-Pediatric Liver Transplantation.
Authors: Eguchi, Susumu / Takatsuki, Mitsuhisa / Hidaka, Masaaki / Soyama, Akihiko / Muraoka, Izumi / Tomonaga, Tetsuo / Shimokawa, Isao / Kanematsu, Takashi
Issue Date: May-2011
Publisher: Springer
Citation: Digestive diseases and sciences, 56(5), pp.1542-1547; 2011
Abstract: BACKGROUND: A grafted donor liver should grow and survive under the different conditions presented by a liver transplantation recipient. It has remained unclear, however, whether the age of a grafted liver can be modulated by recipient factors. AIMS: This study investigated whether a grafted aged donor liver can be rejuvenated in a pediatric recipient. METHODS: Of 119 living donor liver transplants, ten pairs were adult-to-pediatric combinations. Senescence marker protein-30 (SMP-30), which is a protein that is remarkably reduced upon aging, was used as a senescence marker. Immunohistochemical staining for SMP-30 was performed in biopsy specimen after living donor liver transplantation (LDLT). Re-expression of SMP-30 was investigated in a biopsied adult liver (n = 6) that had been transplanted in a pediatric recipient. RESULTS: A remarkable expression of SMP-30 was seen in a control pediatric normal liver in comparison with that in an aged adult donor biopsy. Re-expression or an increase in SMP-30 was not observed in the liver of any pediatric recipient who had received an adult liver. CONCLUSION: An adult grafted liver does not appear to rejuvenate in a pediatric recipient.
Keywords: Graft / Living donor liver transplantation / Pediatric / Rejuvenation / Senescence marker protein-30
URI: http://hdl.handle.net/10069/24461
ISSN: 01632116
DOI: 10.1007/s10620-010-1445-5
PubMed ID: 20936349
Rights: © Springer Science+Business Media, LLC 2010 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24461

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