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Failure to confirm CNVs as of aetiological significance in twin pairs discordant for schizophrenia.


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タイトル: Failure to confirm CNVs as of aetiological significance in twin pairs discordant for schizophrenia.
著者: Ono, Shinji / Imamura, Akira / Tasaki, Shinya / Kurotaki, Naohiro / Ozawa, Hiroki / Yoshiura, Koh-ichiro / Okazaki, Yuji
発行日: 2010年10月
出版者: Australian Academic Press
引用: Twin research and human genetics, 13(5), pp.455-460; 2010
抄録: Copy number variations (CNVs) are common structural variations in the human genome that strongly affect genomic diversity and can play a role in the development of several diseases, including neurodevelopmental disorders. Recent reports indicate that monozygotic twins can show differential CNV profiles. We searched CNVs in monozygotic twins discordant for schizophrenia to identify susceptible loci for schizophrenia. Three pairs of monozygotic twins discordant for schizophrenia were subjected to analysis. Genomic DNA samples were extracted from peripheral blood lymphocytes. We adopted the Affymetrix Genome-Wide Human SNP (Single Nucleotide Polymorphism) Array 6.0 to detect copy number discordance using Partek Genomics Suite 6.5 beta. In three twin pairs, however, validations by quantitative PCR and DNA sequencing revealed that none of the regions had any discordance between the three twin pairs. Our results support the hypothesis that epigenetic changes or fluctuation in developmental process triggered by environmental factors mainly contribute to the pathogenesis of schizophrenia. Schizophrenia caused by strong genetics factors including copy number alteration or gene mutation may be a small subset of the clinical population.
キーワード: CNVs / Epigenetic change / Genotype / Monozygotic twin / Schizophrenia
URI: http://hdl.handle.net/10069/24532
ISSN: 18324274
DOI: 10.1375/twin.13.5.455
PubMed ID: 20874467
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24532

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