DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > University Hospital > Articles in academic journal >

Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients.


File Description SizeFormat
CliImm138_146.pdf174.06 kBAdobe PDFView/Open

Title: Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients.
Authors: Kawasaki, Eiji / Nakamura, Kan / Kuriya, Genpei / Satoh, Tsuyoshi / Kobayashi, Masakazu / Kuwahara, Hironaga / Abiru, Norio / Yamasaki, Hironori / Matsuura, Nobuo / Miura, Junnosuke / Uchigata, Yasuko / Eguchi, Katsumi
Issue Date: Feb-2011
Publisher: Elsevier Inc.
Citation: Clinical immunology, 138(2), pp.146-153; 2011
Abstract: The aim of this study was to evaluate the humoral autoreactivity to zinc transporter 8 (ZnT8) depending on the clinical phenotype of type 1 diabetes (T1D). ZnT8 autoantibodies (ZnT8A) were determined by radioimmunoassay using carboxy-terminal ZnT8 constructs in 57 childhood-onset, 97 adult-onset, and 85 fulminant T1D. The ZnT8A frequency was higher in childhood-onset patients and decreased with increasing age of onset from 70% to 24% (P(trend)<0.005). None of the patients with fulminant T1D was positive for ZnT8A. There were at least two distinct ZnT8A epitope patterns associated with the aa325-restriction, childhood-onset patients have aa325-nonrestricted response more frequently compared to the adult-onset group (P<0.05). The level of ZnT8A was inversely associated with the copy number of HLA-DR4 allele (P<0.05). These results suggest differences in the humoral autoreactivity to ZnT8 depending on the clinical phenotype, which should provide strategy for autoantibody measurement in subjects to allow early diagnosis of autoimmune T1D.
Keywords: Autoantibodies / Epitope / Fulminant / HLA / Type 1 diabetes / Zinc transporter-8
URI: http://hdl.handle.net/10069/24533
ISSN: 15216616
DOI: 10.1016/j.clim.2010.10.007
PubMed ID: 21067978
Rights: © 2010 Elsevier Inc. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24533

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace