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キノンの選択的蛍光・化学発光定量法の開発と環境・生体分析への応用


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Title: キノンの選択的蛍光・化学発光定量法の開発と環境・生体分析への応用
Other Titles: Development of Selective Determination Methods for Quinones with Fluorescence and Chemiluminescence Detection and Their Application to Environmental and Biological Samples
Authors: 岸川, 直哉
Authors (alternative): Kishikawa, Naoya
Issue Date: Oct-2010
Publisher: 日本薬学会 / The Pharmaceutical Society of Japan
Citation: YAKUGAKU ZASSHI, 130(10), pp.1319-1324; 2010
Abstract: Quinones are compounds that have various characteristics such as a biological electron transporter, an industrial product and a harmful environmental pollutant. Therefore, an effective determination method for quinones is required in many fields. This review describes the development of sensitive and selective determination methods for quinones based on some detection principles and their application to analyses in environmental, pharmaceutical and biological samples. Firstly, a fluorescence method was developed based on fluorogenic derivatization of quinones and applied to environmental analysis. Secondly, a luminol chemiluminescence method was developed based on generation of reactive oxygen species through the redox cycle of quinone and applied to pharmaceutical analysis. Thirdly, a photo-induced chemiluminescence method was developed based on formation of reactive oxygen species and fluorophore or chemiluminescence enhancer by the photoreaction of quinones and applied to biological and environmental analyses.
Keywords: Biological analysis / Chemiluminescence / Environmental analysis / Fluorescence / HPLC / Quinone
URI: http://hdl.handle.net/10069/24534
ISSN: 00316903
Rights: Copyright (c) 2010 by the PHARMACEUTICAL SOCIETY OF JAPAN
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24534

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