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Cyclosporin A and phenytoin modulate inflammatory responses.


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タイトル: Cyclosporin A and phenytoin modulate inflammatory responses.
著者: Suzuki, A M M / Yoshimura, Atsutoshi / Ozaki, Y / Kaneko, T / Hara, Y
発行日: 2009年12月 1日
出版者: International and American Associations for Dental Research
引用: Journal of dental research, 88(12), pp.1131-1136; 2009
抄録: Gingival overgrowth is a common side-effect of administration of the immunosuppressant cyclosporin A and the anti-epileptic drug phenytoin. While cyclosporin-induced gingival overgrowth is often accompanied by gingival inflammation, phenytoin-induced gingival overgrowth usually forms fibrotic lesions. To determine whether these drugs alter the inflammatory responses of gingival fibroblasts, we investigated the effects of cyclosporin and phenytoin on Toll-like receptor (TLR)-mediated responses to microbial components. In Chinese hamster ovary reporter cell lines, cyclosporin alone triggered signaling, whereas phenytoin down-regulated signaling induced by the TLR2 or TLR4 ligand. In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses. Cyclosporin also augmented CD54 expression in gingiva of mice injected with lipopolysaccharide. These results indicated that cyclosporin positively and phenytoin negatively modulated inflammatory responses of human gingival fibroblasts.
キーワード: Cyclosporin A / Gingival overgrowth / Inflammation / Phenytoin / TLR
URI: http://hdl.handle.net/10069/24540
ISSN: 00220345
DOI: 10.1177/0022034509350566
PubMed ID: 19897783
関連リンク : http://hdl.handle.net/10069/24786
権利: (c) 2009 by International & American Associations for Dental Research / The final, definitive version of this paper has been published in Journal of dental research, 88(12), Dec. 2009 by SAGE Publications Ltd, All rights reserved. (c) 2009 by International & American Associations for Dental Research
資料タイプ: Journal Article
原稿種類: author
出現コレクション:040 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24540

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