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Non-receptor Protein Tyrosine Kinase Fes as a Candidate for Anticancer Molecular Targeting Therapy


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タイトル: Non-receptor Protein Tyrosine Kinase Fes as a Candidate for Anticancer Molecular Targeting Therapy
著者: Kanda, Shigeru / Miyata, Yasuyoshi / Kanetake, Hiroshi
発行日: 2008年
出版者: Nova Science Publishers
引用: Oncogene Proteins: Structure, Functions and Analyses, pp.209-221; 2008
抄録: Fes (also known as Fps), together with Fer, form the nonreceptor protein tyrosine kinase subfamily. The expression of Fes in normal tissues has been shown to be limited to monocytic hematopoietic cells, endothelial cells, and some neuronal and epithelial cells. Studies using mice expressing activated mutant Fes or cultured endothelial cells indicated that Fes might be involved in pathological angiogenesis, suggesting it could be a potential target for antiangiogenic therapy. Fes was initially identified as a protooncogene product. However, recent studies have indicated that Fes may act also as a tumor suppressor protein in some carcinomas, such as colon cancer, based on the identification of inactivating mutated Fes in colon cancer tissues and downregulated expression of Fes in some cancer cells. Thus, during treatment of these cancers, inhibition of Fes activity may stimulate progression of the pathological process. In this short communication, we will review the recent reports on the roles of Fes in tumor progression and discuss the problems that must be solved before targeting of this kinase in any anti-cancer therapy.
記述: Editors: Peter B. Murphy and Jason R. Clarke
URI: http://hdl.handle.net/10069/24553
ISBN: 978-1-60456-259-0
権利: © 2008 Nova Science Publishers, Inc.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24553

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