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The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer


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タイトル: The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer
著者: Kanda, Shigeru / Miyata, Yasuyoshi
発行日: 2011年 1月 1日
出版者: Frontiers in Bioscience
引用: Frontiers in Bioscience, 16, pp.1024-1035; 2011
抄録: Angiogenesis is implicated in many pathological conditions, including cancer progression. Novel approaches have enabled an understanding of how endothelial cellular processes are regulated in vivo during angiogenesis. Key players in angiogenesis are vascular endothelial growth factors (VEGFs) and Notch ligands. However, mechanisms of angiogenic responses by other proangiogenic factors in vivo are largely unknown. Research using cultured endothelial cells has shown that c-Fes is involved in the activation of phosphoinositide 3-kinase (PI3-kinase) downstream of a variety of cytokine receptors. The PI3-kinase/c-Akt pathway regulates cell survival, migration, and morphological differentiation of endothelial cells during angiogenesis, and c-Fes thus may be a potential target of anti-cancer therapy, especially for patients with anti-VEGF refractory cancer. In addition, a number of experiments have shown that a bone marrow-derived monocytic lineage regulates angiogenesis, and c-Fes is also expressed in these cells. Roles for c-Fes during angiogenesis will be the focus of extensive research in the future.
URI: http://hdl.handle.net/10069/24563
ISSN: 10939946
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24563

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