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The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.

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Title: The differential role of L-selectin and ICAM-1 in Th1-type and Th2-type contact hypersensitivity.
Authors: Ogawa, Asako / Yoshizaki, Ayumi / Yanaba, Koichi / Ogawa, Fumihide / Hara, Toshihide / Muroi, Eiji / Takenaka, Motoi / Shimizu, Kazuhiro / Hasegawa, Minoru / Fujimoto, Manabu / Tedder, Thomas F / Sato, Shinichi
Issue Date: Jun-2010
Publisher: Nature Publishing Group
Citation: The Journal of investigative dermatology, 130(6), pp.1558-1570; 2010
Abstract: Sensitization and challenge using DNFB induce contact hypersensitivity (CHS) with predominant type 1 helper (Th1) cell infiltration, whereas those using FITC generate CHS with Th2 cell infiltration. CHS results from inflammatory cell infiltration, a process that is highly regulated by the expression of multiple adhesion molecules. We attempted to determine the role of L-selectin and ICAM-1 in Th1- and Th2-type CHS induced by DNFB or FITC in mice lacking either L-selectin, ICAM-1, or both. Th1-type CHS induced by DNFB was inhibited by L-selectin and/or ICAM-1 deficiency, which was associated with reduced IFN-gamma expression. Similarly, Th2-type CHS induced by FITC was inhibited by L-selectin deficiency. However, Th2-type CHS was increased by ICAM-1 deficiency and accompanied by increased Th2 cytokine expression. Infiltration of in vitro-generated Th1 cells into the FITC-challenged skin decreased in ICAM-1-deficient mice, whereas in vitro-generated Th2 cell infiltration increased, suggesting that ICAM-1 mediates Th1 cell migration and that in the absence of ICAM-1, Th1 cell recruitment decreased, whereas relative Th2 cell migration increased. These results suggest that ICAM-1 mediates Th1 cell recruitment irrespective of DNFB or FITC and that L-selectin recruits Th1 cells in Th1-type CHS, whereas it recruits Th2 cells in Th2-type CHS.
URI: http://hdl.handle.net/10069/24565
ISSN: 0022202X
DOI: 10.1038/jid.2010.25
PubMed ID: 20182448
Rights: © 2010 The Society for Investigative Dermatology.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24565

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