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Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice


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Title: Induction of Late-onset Spontaneous Autoimmune Thyroiditis by a Single Low-dose Irradiation in Thyroiditis-prone Non-obese Diabetic-H2h4 Mice
Authors: Nagayama, Yuji / Ichikawa, Tatsuki / Saitoh, Ohki / Abiru, Norio
Issue Date: 16-Nov-2009
Publisher: 日本放射線影響学会 / The Japan Radiation Research Society
Citation: Journal of radiation research, 50(6), pp.573-577; 2009
Abstract: The previous data regarding the effect of irradiation on thyroid autoimmunity are controversial. We have recently reported the exacerbation of autoimmune thyroiditis by a single low dose (0.5 Gy) of whole body irradiation in thyroiditis-prone non-obese diabetic (NOD)-H2h4 mice treated with iodine for 8 weeks. However, it is uncertain in that report whether the results obtained by the provision of iodine in a relatively short period of time (8 weeks) accurately reflects the long-term consequences of low-dose irradiation on thyroid autoimmunity. Therefore, we repeated these experiments with mice that were monitored after irradiation without iodine treatment for up to 15 months. We found that a single low-dose (0.5 Gy) irradiation increased the incidence and severity of thyroiditis and the incidence and titers of anti-thyroglobulin autoantibodies at 15 months of age. The numbers of splenocytes and percentages of various lymphocyte subsets were not affected by irradiation. Thus, we conclude that low-dose irradiation also exacerbates late-onset spontaneous thyroiditis in NOD-H2h4 mice; one plausible explanation for this may be the acceleration of immunological aging by irradiation.
Keywords: Autoimmune thyroiditis / Iodine / Low-dose irradiation / NOD-H2 h4 mice
URI: http://hdl.handle.net/10069/24586
ISSN: 04493060
DOI: 10.1269/jrr.09067
Rights: Copyright (c) 2009 by THE JAPAN RADIATION RESEARCH SOCIETY
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24586

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