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Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women.


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タイトル: Age-related changes in bone density, geometry and biomechanical properties of the proximal femur: CT-based 3D hip structure analysis in normal postmenopausal women.
著者: Ito, Masako / Nakata, Tomoko / Nishida, Akifumi / Uetani, Masataka
発行日: 2010年 3月 1日
出版者: Elsevier Inc.
引用: Bone, 48(3), pp.627-630; 2011
抄録: The geometry as well as bone mineral density (BMD) of the proximal femur contributes to fracture risk. How and the extent to which they change due to natural aging is not fully understood. We assessed BMD and geometry in the femoral neck and shaft separately, in 59 normal Japanese postmenopausal women aged 54-84years, using clinical computed tomography (CT) and commercially available software, at baseline and 2-year follow-up. This system detected significant reductions over the 2-year interval in total BMD (%change/year=-0.900±0.257, p<0.0005), cortical cross-sectional area (CSA) (-0.800±0.423%/year, p<0.05) and cortical thickness (-1.120±0.453%/year, p<0.01) in the femoral neck. In the femoral shaft, cortical BMD decreased significantly (-0.642±0.188%/year, p<0.005). Regarding biomechanical parameters in the femoral neck, the cross-sectional moment of inertia (CSMI) and section modulus (SM) decreased (-1.38±3.65%/year, p<0.01 and -1.37±2.96%/year, p<0.005) and the buckling ratio (BR) increased significantly (1.48±4.81%/year, p<0.05), whereas no changes were found in the femoral shaft. The distinct patterns of age-related changes in the geometry and biomechanical properties in the femoral neck and shaft suggest that improved geometric measures are possible with the current non-invasive method using clinical CT.
キーワード: Bone mineral density (BMD) / Computed tomography (CT) / Hip geometry / Osteoporosis
URI: http://hdl.handle.net/10069/24600
ISSN: 87563282
DOI: 10.1016/j.bone.2010.11.007
PubMed ID: 21087686
権利: Copyright © 2010 Elsevier Inc. All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24600

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