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Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method


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タイトル: Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method
著者: Ioku, Koji / Kamitakahara, Masanobu / Ikeda, Tohru
発行日: 2010年11月24日
出版者: American Institute of Physics
引用: AIP Conference Proceedings, 1251, pp.304-307; 2010
抄録: Hydrothermal processing plays a key role in the synthesis of biomaterials with excellent biocompatibility in the physiological environment. Especially, calcium phosphates are paid to much attention for the regenerative medicine. Two kinds of porous materials of hydroxyapatite with 70% porosity were prepared. One of them is a newly developed calcium-deficient hydroxyapatite composed of rod-shaped particles of about 20 μm in length synthesized hydrothermally (HHA) and the other one is the stoichiometric hydroxyapatite (SHA) prepared by the conventional sintering method. These materials were used for animal implantation tests to compare these biological responses. In the rabbit femur, implanted HHA was slowly resorbed and then most of the implanted HHA was resorbed after 72 weeks. The implanted SHA was unresorbed throughout the experimental period. The volume of newly formed bone and the number of osteoclasts in the implanted region were significantly larger in HHA than in SHA after 24 weeks. Results in the present research suggested that the activity of osteoclasts correlated to the bone forming activity of osteoblasts. The method to synthesize biodegradable pure calcium-deficient HA is expected to provide adequate biodegradability and bone replaceability.
キーワード: Hydrothermal / Hydroxyapatite calcium phosphate
URI: http://hdl.handle.net/10069/24780
ISBN: 978-073540798-5
ISSN: 0094243X
権利: © 2010 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.The following article appeared in AIP Conference Proceedings, 1251, pp.304-307; 2010 and may be found at http://dx.doi.org/10.1063/1.3529307.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:040 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24780

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