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Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis


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タイトル: Risk Factors and Prediction of Long-term Outcome in Primary Biliary Cirrhosis
著者: Ishibashi, Hiromi / Komori, Atsumasa / Shimoda, Shinji / Ambrosini, Yoko M. / Gershwin, M. Eric / Nakamura, Minoru
発行日: 2011年
出版者: Japanese Society of Internal Medicine / 日本内科学会
引用: Internal Medicine, 50(1), pp.1-10; 2011
抄録: The natural history of the disease varies greatly among individual patients with primary biliary cirrhosis (PBC). Some patients live long without any symptoms while other patients present jaundice and develop hepatic failure in early phases of the disease. Previous studies showed that the natural course of PBC is altered by the use of ursodeoxy cholic acid (UDCA). In this review we discuss variation in the natural course of the disease and it's alteration by UDCA, and risk factors that predict disease progression. Based on clinical observations, there are three types of clinical evolution in PBC: 1) minimal to slow progression over several years; 2) rapid progression to jaundice and hepatic failure, and 3) progression to portal hypertension without developing deep jaundice. Notably, based on our analyses accelerated progression to jaundice and liver failure are reflected by a sustained serologic presence of anti-gp210 antibodies whereas patients with portal hypertension in the absence of jaundice have anti-centromere autoantibodies. These observations highlight the clinical importance of antinuclear antibody analysis in patients with PBC.
キーワード: Autoantibody / Centromere / gp210 / Natural history / Primary biliary cirrhosis / Prognosis
URI: http://hdl.handle.net/10069/24829
ISSN: 09182918
DOI: 10.2169/internalmedicine.50.4462
権利: Copyright (c) 2011 by The Japanese Society of Internal Medicine
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24829

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