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Recent progress in bone imaging for osteoporosis research.


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タイトル: Recent progress in bone imaging for osteoporosis research.
著者: Ito, Masako
発行日: 2011年 3月
出版者: Springer Verlag
引用: Journal of bone and mineral metabolism, 29(2), pp.131-140; 2011
抄録: Advances in bone imaging techniques have provided tools for analyzing bone structure at the macro-, micro- and nano-level. Quantitative assessment of macrostructure can be achieved using dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), particularly volumetric quantitative CT (vQCT). In vivo quantitative techniques for assessing the microstructure of trabecular bone non-invasively and non-destructively include high-resolution CT (HR-CT) and high-resolution magnetic resonance (HR-MR). Compared with MR imaging, CT-based techniques have the advantage of directly visualizing the bone in the axial skeleton, with high spatial resolution, but the disadvantage of delivering a considerable radiation dose. Micro-CT (μCT), which provides a higher resolution of the microstructure and is principally applicable in vitro, has undergone technological advances such that it is now able to elucidate the physiological skeletal change mechanisms associated with aging and determine the effects of therapeutic intervention on the bone microstructure. In particular, synchrotron μCT (SR-CT) provides a more detailed view of trabecular structure at the nano-level. For the assessment of hip geometry, DXA-based hip structure analysis (HSA) and CT-based HSA have been developed. DXA-based HSA is a convenient tool for analyzing biomechanical properties and for assuming cross-sectional hip geometry based on two-dimensional (2D) data, whereas CT-based HSA provides these parameters three-dimensionally in robust relationship with biomechanical properties, at the cost of greater radiation exposure and the lengthy time required for the analytical procedure. Further progress in bone imaging technology is promising to bring new aspects of bone structure in relation to bone strength to light, and to establish a means for analyzing bone structural properties in the everyday clinical setting.
キーワード: Computed tomography / Finite element model / Geometry / Magnetic resonance / Microstructure
URI: http://hdl.handle.net/10069/24840
ISSN: 09148779
DOI: 10.1007/s00774-010-0258-0
PubMed ID: 21301898
権利: © The Japanese Society for Bone and Mineral Research and Springer 2011 / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24840

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