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Mannich-Type Reaction of N,O-Acetals with Ketones Mediated by a Combination of TiCl4 and PhSiCl3


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Title: Mannich-Type Reaction of N,O-Acetals with Ketones Mediated by a Combination of TiCl4 and PhSiCl3
Authors: Onomura, Osamu / Ikeda, Takashi / Kuriyama, Masami / Matsumura, Yoshihiro / Kamogawa, Satoshi
Issue Date: 2010
Publisher: The Japan Institute of Heterocyclic Chemistry
Citation: HETEROCYCLES, 82(1), pp.325-332; 2010
Abstract: A combination of TiCl4 and PhSiCl3 efficiently conducts the Mannich-type reaction of N,O-acetals with ketones to afford α-substituted cyclic amine derivatives in good yields. This method was applicable to preparation of azabicyclo compounds by the intramolecular Mannich-type reaction.
Keywords: Mannich-Type Reaction / Trichlorosilane / Titanium Tetrachloride / Acetal / Ketone
URI: http://hdl.handle.net/10069/24976
ISSN: 03855414
DOI: 10.3987/COM-09-S(E)2
Rights: © The Japan Institute of Heterocyclic Chemistry.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/24976

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