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Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia


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タイトル: Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia
著者: Okumura, Teruhito / Gonda, Yoshinori / Ioku, Koji / Kamitakahara, Masanobu / Okuda, Takatoshi / Yonezawa, Ikuho / Kurosawa, Hisashi / Asahina, Izumi / Ikeda, Tohru
発行日: 2011年 2月
出版者: 日本セラミックス協会 / The Ceramic Society of Japan
引用: Journal of the Ceramic Society of Japan, 119(1386), pp.101-104; 2011
抄録: Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.
キーワード: Alkaline phosphatase / Beta-tricalcium phosphate / Bone substitute / Healing of bone defect / Hydrothermal route
URI: http://hdl.handle.net/10069/24984
ISSN: 18820743
DOI: 10.2109/jcersj2.119.101
関連リンク : http://hdl.handle.net/10069/26576
権利: ©2011 The Ceramic Society of Japan. All rights reserved.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/24984

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