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Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients

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Title: Case-controlled Study on Risk Factors for the Development of Constipation in Hospitalized Patients
Authors: Ueki, Tetsuya / Nagai, Keiko / Ooe, Nobuharu / Nakashima, Mihoko N. / Nishida, Koyo / Nakamura, Junzo / Nakashima, Mikiro
Issue Date: Mar-2011
Publisher: The Pharmaceutical Society of Japan / 日本薬学会
Citation: 薬学雑誌, 131(3), pp.469-476; 2011
Abstract: Constipation is a common problem in hospitalized patients; however, the relative risks of its development with various factors have not been clarified. To clarify the risk factors associated with constipation, we performed a case-controlled study of 165 hospitalized patients who were not laxative users on admission. They were divided into case (n=35) and control (n=130) groups according to laxative administration during hospitalization. Comparison of the patient backgrounds in the two groups revealed significant differences in the activities of daily living, length of fasting, rest level on admission, cerebrovascular disease, and administration of hypnotics. Multiple logistic regression analysis using these five factors as autonomous variables showed that administration of hypnotics (odds ratio, 2.79; 95% confidence interval, 1.10-7.06; p=0.031) was significantly related to laxative use. Therefore, the administration of hypnotics may be the principal cause of constipation development in hospitalized patients and they should be used with caution.
Keywords: Adverse drug reaction / Constipation / Hospitalized patient / Hypnotics / Laxative / Risk factor
URI: http://hdl.handle.net/10069/25143
ISSN: 00316903
DOI: 10.1248/yakushi.131.469
Rights: Copyright (c) 2011 by the PHARMACEUTICAL SOCIETY OF JAPAN
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/25143

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