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Development and Application of Sensitive Methods with Luminescence Detections for Determination of Biologically Active Compounds


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タイトル: Development and Application of Sensitive Methods with Luminescence Detections for Determination of Biologically Active Compounds
著者: Nakashima, Kenichiro
発行日: 2011年 2月
出版者: The Pharmaceutical Society of Japan / 日本薬学会
引用: JOURNAL OF HEALTH SCIENCE, 57(1), pp.10-21; 2011
抄録: This review describes a comprehensive investigation in our laboratory focusing on development of sensitive analytical methods by utilizing luminescence detections, and leading to practical applications for quantification of biologically related compounds, especially drugs of abuse. The developed methods mainly used a high-performance liquid chromatographic separation technique with fluorescence and chemiluminescence detections. The main tar- gets of our investigation are ultra-small amounts of biologically active compounds, especially centered on abused drugs such as stimulants, narcotics and anorectics in various matrices. Furthermore, drug-drug interaction of these compounds was also examined. The results obtained in our study might contribute to the prediction of and the pro- tection of human health from the risks of abused drugs. The developed methods might be useful for pharmaceutical, clinical and forensic studies on drugs of abuse as well as other important biologically active compounds.
キーワード: Biologically active compound / Drugs of abuse / HPLC / Luminescence detection
URI: http://hdl.handle.net/10069/25145
ISSN: 13449702
DOI: 10.1248/jhs.57.10
権利: Copyright (c) 2011 by The Pharmaceutical Society of Japan
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25145

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