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Effects of smoking cessation on gastric emptying in smokers.

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タイトル: Effects of smoking cessation on gastric emptying in smokers.
著者: Kadota, Koichiro / Takeshima, Fuminao / Inoue, Keita / Takamori, Ken-Ichi / Yoshioka, Sumako / Nakayama, Seiko / Abe, Koh / Mizuta, Yohei / Kohno, Shigeru / Ozono, Yoshiyuki
発行日: 2010年 4月
出版者: Lippincott Williams & Wilkins, Inc.
引用: Journal of clinical gastroenterology, 44(4), pp.71-75; 2010
抄録: BACKGROUND: Smoking cessation can lead to changes in appetite and weight gain in some patients; thus, smoking cessation may alter gastrointestinal motility. Effects of smoking cessation on gastric emptying in smokers have not been established. AIM: This study sought to determine how smoking cessation affects gastric emptying in smokers. METHODS: Participant group comprised 53 habitual smokers and 12 healthy nonsmokers. Habitual smokers were treated for 2 months with transdermal nicotine patches. Gastric emptying was studied using C acetate breath tests at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Maximal CO2 excretion time (Tmax), CO2 excretion half-life (T1/2), and parameters beta and kappa, representing initial and subsequent gastric-emptying phases, respectively, were determined using conventional formulae. RESULTS: Before smoking cessation, Tmax was reached significantly later in smokers (0.94+/-0.3 h, P=0.014) than in controls (0.89+/-0.1 h). At 1 week after the end of treatment, Tmax was significantly decreased (from 1.05+/-0.32 h to 0.72+/-0.64 h, P=0.003). T1/2 also tended to decrease, but not significantly. Although beta was decreased significantly (from 2.46+/-0.40 to 2.17+/-0.58, P=0.022), kappa was unchanged. However, by 9 weeks after the end of treatment, Tmax (1.28+/-0.69 h) had increased to levels seen before treatment. CONCLUSIONS: Smoking cessation temporarily accelerates gastric emptying, and decreases in beta suggest that initial-phase gastric emptying accelerates after smoking cessation. The temporary acceleration of gastric emptying after smoking cessation may be involved in the temporary increase in appetite and weight gain seen after smoking cessation.
キーワード: Gastric emptying / Smoking cessation
URI: http://hdl.handle.net/10069/25156
ISSN: 01920790
DOI: 10.1097/MCG.0b013e3181be9a0f
PubMed ID: 20305466
関連リンク : http://hdl.handle.net/10069/24897
権利: © 2010 Lippincott Williams & Wilkins, Inc. / This is a non-final version of an article published in final form in Journal of clinical gastroenterology, 44(4), pp.71-75; 2010.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25156



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