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Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma


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Title: Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma
Authors: Akahoshi, Hiroshi / Taura, Naota / Ichikawa, Tatsuki / Miyaaki, Hisamitsu / Akiyama, Motohisa / Miuma, Satoshi / Ozawa, Eisuke / Takeshita, Shigeyuki / Muraoka, Toru / Matsuzaki, Toshihisa / Ohtani, Masashi / Isomoto, Hajime / Matsumoto, Takehiro / Takeshima, Fuminao / Nakao, Kazuhiko
Issue Date: May-2010
Publisher: Spandidos Publications
Citation: Oncology Reports, 23(5), pp.1317-1323; 2010
Abstract: The number and ratio of both HBsAg- and HCV Abnegative hepatocellular carcinoma (HCC-nonBC) cases have been steadily increasing in Japan. The aim of this study was to examine the frequency of detection of HCC-nonBC by screening methods and to elucidate the clinical characteristics of HCC-nonBC compared with those of hepatitis C and/or B virus-associated HCC (HCC-virus). We recruited 624 patients with HCC who were diagnosed between 1982 and 2007 at the Department of Gastroenterology and Hepatology, Nagasaki University Hospital. They were categorized into 2 groups as follows: i) 550 were included in the HCC-virus group: positive for HBsAg and/or positive for HCV Ab, and ii) 74 were included in the HCC-nonBC group: negative for both HBsAg and HCV Ab. The follow-up patterns until the initial detection of HCC and the survival rates were analyzed and compared between the 2 groups. Multivariate analysis identified follow-up, alcohol consumption, albumin level, total bilirubin level, α-fetoprotein (AFP) level, and tumor-node-metastasis (TNM) stage as independent and significant risk factors for prognosis. Among the 397 patients with HCC in TNM stage I or II, multivariate analysis identified the cause of liver disease, gender, Child-Pugh score, serum albumin level and TNM stage as independent and significant risk factors for prognosis. We reported that the poor prognoses of patients with HCC-nonBC were attributable to its late detection in an advanced condition due to the absence of a surveillance system for the early detection of HCC. However, in early-stage patients, patients with HCC-nonBC showed significantly better prognosis than those in the HCC-virus group.
Keywords: Hepatocellular carcinoma / Viral hepatitis
URI: http://hdl.handle.net/10069/25191
ISSN: 1021335X
DOI: 10.3892/or-00000766
Relational Links: http://hdl.handle.net/10069/25126
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/25191

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