DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 学術雑誌論文 >

Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance


ファイル 記述 サイズフォーマット
IntMed50_707.pdf136.76 kBAdobe PDF本文ファイル

タイトル: Early Effects of Smoking Cessation and Weight Gain on Plasma Adiponectin Levels and Insulin Resistance
著者: Inoue, Keita / Takeshima, Fuminao / Kadota, Koichiro / Yoda, Aya / Tatsuta, Yoichi / Nagaura, Yuki / Yoshioka, Sumako / Nakamichi, Seiko / Nakao, Kazuhiko / Ozono, Yoshiyuki
発行日: 2011年 4月 1日
出版者: 日本内科学会 / The Japanese Society of Internal Medicine
引用: Internal Medicine, 50(7), pp.707-712; 2011
抄録: Background Tobacco smoking is a major risk factor for atherosclerotic and cardiovascular disease. Studies have found evidence that smoking cessation is associated with weight gain, which is itself a leading cause of cardiovascular disease. Aim The present study sought to determine how smoking cessation and associated weight gain affect adiponectin levels and insulin resistance. Methods Fifty-two male habitual smokers were treated for 2 months with transdermal nicotine patches, and the 28 subjects who successfully quit smoking were analyzed. Subjects were divided into two sub-groups according to their weight change: weight maintainers and weight gainers. Serum adiponectin levels and the homeostasis model assessment ratio (HOMA-R) were evaluated at the beginning of the study, and at 1 week and 9 weeks after cessation of patch use. Results In weight gainers (n=18), serum adiponection levels tended to increase at 1 week after the end of treatment (mean difference 0.4±1.0 μg/mL, p=0.08). Moreover, after 9 weeks, adiponectin levels were significantly decreased in weight gainers (mean difference between 1 week and 9 weeks 0.8±0.9 μg/mL, p=0.002). In weight maintainers, adiponectin levels increased slightly after smoking cessation, but changes were not significant. In weight gainers, HOMA-R index was significantly increased (mean difference between baseline and 9 weeks 0.4±0.7, p=0.01), while in weight maintainers, HOMA-R index showed no differences throughout the study. Conclusion Our findings suggest that the adverse effects of weight gain attenuate some of the beneficial effects of smoking cessation.
キーワード: Adiponectin / Insulin resistance / Smoking cessation / Weight gain
URI: http://hdl.handle.net/10069/25426
ISSN: 09182918
DOI: 10.2169/internalmedicine.50.4600
関連リンク : http://hdl.handle.net/10069/26687
権利: Copyright (c) 2011 by The Japanese Society of Internal Medicine
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25426

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace