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A single centre retrospective analysis of AECG classification criteria for primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a Japanese population.


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Title: A single centre retrospective analysis of AECG classification criteria for primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a Japanese population.
Authors: Nakamura, Hideki / Kawakami, Atsushi / Iwamoto, Naoki / Okada, Akitomo / Yamasaki, Satoshi / Tamai, Mami / Ida, Hiroaki / Takagi, Yukinori / Hayashi, Tomayoshi / Aoyagi, Kiyoshi / Nakamura, Takashi / Eguchi, Katsumi
Issue Date: Jul-2010
Publisher: Oxford University Press
Citation: Rheumatology, 49(7), pp.1290-1293; 2010
Abstract: OBJECTIVE: To assess the usefulness and performance of the American European Consensus Group (AECG) criteria based on minor salivary gland biopsy (MSGB) in Japanese patients with primary SS. METHODS: Among 208 MSGB cases, we retrospectively selected 112 subjects who satisfied the complete set of AECG classification criteria. Of the 112 subjects studied, 63 primary SS patients and 49 non-SS group subjects were classified according to the AECG criteria. The contribution of subjective and objective components was statistically analysed. RESULTS: Sex, dry eye, Saxon test, Schirmer's test, anti-SSA/Ro antibody, MSGB grading and sialography statistically contributed to the diagnosis. Multiple logistic regression analysis showed that positive MSGB [odds ratio (OR) 105; 95% CI 13, 849), positive anti-SSA/Ro antibody (OR 96; 95% CI 10, 923), a positive Saxon test (OR 46; 95% CI, 6, 340) and the existence of dry eye (OR 8, 95% CI 2, 43) were associated with the diagnosis of primary SS. Among the components of the AECG criteria, MSGB and anti-SSA/Ro antibody were very strong contributors. Furthermore, the abnormal-finding positive rate in sialography significantly correlated with MSGB grading (P-value for trend = 0.0006), although other subjective and objective components were not associated with MSGB grading. CONCLUSION: The usefulness of the AECG criteria for Japanese primary SS patients was confirmed.
Keywords: Classification criteria / Minor salivary gland biopsy / Sjögren's syndrome
URI: http://hdl.handle.net/10069/25439
ISSN: 14620324
DOI: 10.1093/rheumatology/keq075
PubMed ID: 20338890
Rights: © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org / This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version Rheumatology, 49(7), pp.1290-1293; 2010 is available online at: http://dx.doi.org/10.1093/rheumatology/keq075.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/25439

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