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Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis.


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Title: Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis.
Authors: Fujita, Hanako / Sakamoto, Noriho / Ishimatsu, Yuji / Kakugawa, Tomoyuki / Hara, Shintaro / Hara, Atsuko / Amenomori, Misato / Ishimoto, Hiroshi / Nagata, Towako / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: Apr-2011
Publisher: Karger AG,
Citation: Respiration, 81(5), pp.420-430; 2011
Abstract: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibrosis and a poor prognosis. Alveolar epithelial cells (AECs) are considered to play important roles by releasing growth factors and matrix metalloproteinases (MMPs) and by being involved in epithelial mesenchymal transition in IPF. Doxycycline hydrochloride (DOXY), an inhibitor of MMPs, attenuates pulmonary fibrosis in models and in patients with IPF; however, the mechanism of this action remains obscure.
Keywords: Alveolar epithelial cells / Connective tissue growth factor / Epithelial mesenchymal transition / Fibroblast / Smad
URI: http://hdl.handle.net/10069/25456
ISSN: 00257931
DOI: 10.1159/000324080
PubMed ID: 21502778
Relational Links: http://hdl.handle.net/10069/26718
Rights: Copyright © 2011 S. Karger AG, Basel
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/25456

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