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Characterization of a Novel Proteinous Toxin from Sea Anemone Actineria villosa.

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タイトル: Characterization of a Novel Proteinous Toxin from Sea Anemone Actineria villosa.
著者: Uechi, Gen-Ichiro / Toma, Hiromu / Arakawa, Takeshi / Sato, Yoshiya
発行日: 2011年 8月
引用: The Protein Journal, 30(6), pp.422-428; 2011
抄録: The sea anemone Actineria villosa expresses a lethal protein toxin. We isolated a novel 120-kDa protein, Avt120, from partially purified toxin and found it to possess extremely strong lethal activity. The 3,453-bp Avt120 gene translates to a 995-amino acid protein. The 50% lethal dose (LD(50)) of purified Avt120 in mice was 85.17 ng. Among several tested cell lines, Colo205 cells were most sensitive to Avt120: 50% of them were damaged by 38.4 ng/mL Avt120. Avt120 exerted ATP degradation activity (10 μmol ATP h(-1) mg(-1)), which was strongly inhibited by ganglioside GM1 to decrease the cytotoxicity of Avt120.
キーワード: Actineria villosa / Avt120 / ATP degradation activity / Ganglioside / Cytotoxic
URI: http://hdl.handle.net/10069/25469
ISSN: 1875-8355
DOI: 10.1007/s10930-011-9347-8
PubMed ID: 21769623
資料タイプ: Journal Article
原稿種類: author
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25469



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