DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 学術雑誌論文 >

False-Positive Accumulation of Metaiodobenzylguanidine in a Case with Acute Intermittent Porphyria

ファイル 記述 サイズフォーマット
IntMed50_1029.pdf686.17 kBAdobe PDF本文ファイル

タイトル: False-Positive Accumulation of Metaiodobenzylguanidine in a Case with Acute Intermittent Porphyria
著者: Masuda, Tomoko / Ota, Rie / Ando, Takao / Maeda, Naoto / Horie, Yutaka / Yoshimura, Toshiro / Motomura, Masakatsu / Kawakami, Atsushi
発行日: 2011年 5月 1日
出版者: The Japanese Society of Internal Medicine / 日本内科学会
引用: Internal Medicine, 50(9), pp.1029-1032; 2011
抄録: We report a 36-year-old woman presenting with hypertensive encephalopathy followed by bulbar palsy and quadriplegia. After an extensive screening for secondary causes of hypertension, the patient was suspected of having pheochromocytoma due to increased levels of catecholamines in the plasma and the urine, and positive 131I-metaiodobenzylguanidine (MIBG) accumulation in the gallbladder. However, MIBG accumulation was not reproducible without any tumors accompanying this accumulation in the gallbladder. A diagnosis of acute intermittent porphyria was finally confirmed based on the characteristic pictures, increased urinary excretion of porphobilinogen, and identification of a heterozygous missense mutation of R173W in the hydroxymethylbilane synthase gene. This case highlights a pitfall in utilizing MIBG to detect a source of excessive catecholamine and also suggests the importance of having a complete clinical history and extensive work-up of any possible differential diagnosis. We also review the potential mechanism by which falsepositive MIBG accumulation occurs.
キーワード: Acute intermittent porphyria / False-positive / MIBG / Pheochromocytoma
URI: http://hdl.handle.net/10069/25470
ISSN: 09182918
DOI: 10.2169/internalmedicine.50.5096
権利: Copyright (c) 2011 by The Japanese Society of Internal Medicine
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25470



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace