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Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.


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タイトル: Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis.
著者: Kurotaki, Naohiro / Tasaki, Shinya / Mishima, Hiroyuki / Ono, Shinji / Imamura, Akira / Kikuchi, Taeko / Nishida, Nao / Tokunaga, Katsushi / Yoshiura, Koh-ichiro / Ozawa, Hiroki
発行日: 2011年 5月31日
出版者: Public Library of Science
引用: PLoS One, 6(5), e20589; 2011
抄録: The recent development of high-resolution DNA microarrays, in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped, enables the rapid identification of susceptibility genes for complex diseases. Clusters of these SNPs may show runs of homozygosity (ROHs) that can be analyzed for association with disease. An analysis of patients whose parents were first cousins enables the search for autozygous segments in their offspring. Here, using the Affymetrix® Genome-Wide Human SNP Array 5.0 to determine ROHs, we genotyped 9 individuals with schizophrenia (SCZ) whose parents were first cousins. We identified overlapping ROHs on chromosomes 1, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 19, 20, and 21 in at least 3 individuals. Only the locus on chromosome 5 has been reported previously. The ROHs on chromosome 5q23.3-q31.1 include the candidate genes histidine triad nucleotide binding protein 1 (HINT1) and acyl-CoA synthetase long-chain family member 6 (ACSL6). Other overlapping ROHs may contain novel rare recessive variants that affect SCZ specifically in our samples, given the highly heterozygous nature of SCZ. Analysis of patients whose parents are first cousins may provide new insights for the genetic analysis of psychiatric diseases.
URI: http://hdl.handle.net/10069/25481
ISSN: 19326203
DOI: 10.1371/journal.pone.0020589
PubMed ID: 21655227
権利: © 2011 Kurotaki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25481

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