DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 110 医歯薬学総合研究科 > 110 学術雑誌論文 >

Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells


ファイル 記述 サイズフォーマット
JRR52_369.pdf370.88 kBAdobe PDF本文ファイル

タイトル: Norepinephrine Enhances Radiosensitivity in Rat Ileal Epithelial Cells
著者: Matsuu-Matsuyama, Mutsumi / Okaichi, Kumio / Shichijo, Kazuko / Nakayama, Toshiyuki / Nakashima, Masahiro / Sekine, Ichiro
発行日: 2011年 5月31日
出版者: Journal of Radiation Research Editorial Committee / 日本放射能影響学会
引用: Journal of Radiation Research, 52(3), pp.369-373; 2011
抄録: We previously reported that the apoptosis index in jejunal crypt cells after X irradiation was greater in spontaneously hypertensive rats than in Wistar-Kyoto rats. Moreover, these same cells showed a suppression of apoptosis when reserpine was administered to induce sympathetic dysfunction in spontaneously hypertensive rats or Wistar-Kyoto rats.1) Whether the hyperfunction of the sympathetic nervous system is involved in the high susceptibility of the jejunal crypt cells to radiation-induced apoptosis was the subject of this study. The effect of norepinephrine (NE) on cell survival was examined using the colony formation assay after X-ray irradiation of rat ileal epithelial cells (IEC-18). The addition of 1 μM NE decreased the surviving fraction of cells irradiated with 6 Gy from 37% to 8%. The radiosensitivity of IEC-18 cells was enhanced by the addition of 1 μM of NE. The irradiation and treatment with NE also resulted in an increased cellular apoptotic rate. These results showing enhanced radiosensitivity of rat ileal epithelial cells by NE suggest that NE may be one of the factors which aggravate acute radiation injury in the intestine.
キーワード: Norepinephrine (NE) / Radiosensitivity / Rat ileal epithelial cells (IEC-18)
URI: http://hdl.handle.net/10069/25484
ISSN: 04493060
DOI: 10.1269/jrr.10155
権利: Copyright (c) 2011 by Journal of Radiation Research Editorial Committee
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25484

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace