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Animal models of middle ear cholesteatoma.

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タイトル: Animal models of middle ear cholesteatoma.
著者: Yamamoto-Fukuda, Tomomi / Takahashi, Haruo / Koji, Takehiko
発行日: 2011年
出版者: Hindawi Publishing Corporation
引用: Journal of Biomedicine & Biotechnology, 2011, article no.394241
抄録: Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism underlying its pathogenesis is limited. To investigate its pathogenesis, different animal models have been used. This paper provides a brief overview of the current status of research in the field of pathogenesis of middle ear acquired cholesteatoma, four types of animal models previously reported on, up-to-date cholesteatoma research using these animal models, our current studies of the local hybrid ear model, and the future prospect of new animal models of middle ear cholesteatoma.
URI: http://hdl.handle.net/10069/25514
ISSN: 11107243
DOI: 10.1155/2011/394241
PubMed ID: 21541229
権利: Copyright © 2011 Tomomi Yamamoto-Fukuda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25514



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