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Low Glomerular Filtration Rate Is Associated With High Prevalence of Vasospastic Angina

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タイトル: Low Glomerular Filtration Rate Is Associated With High Prevalence of Vasospastic Angina
著者: Koga, Seiji / Ikeda, Satoshi / Nakata, Tomoo / Yasunaga, Tomohiko / Takeno, Masayoshi / Koide, Yuji / Maemura, Koji
発行日: 2011年 6月24日
出版者: The Japanese Circulation Society / 日本循環器学会
引用: Circulation Journal, 75(7), pp.1691-1695; 2011
抄録: Background: Although chronic kidney disease is associated with a high prevalence of cardiovascular disease, the relationship between coronary artery spasm and renal dysfunction has not been elucidated. Methods and Results: We evaluated 139 patients with chest pain at rest who had no significant organic stenosis on coronary angiograms and who underwent coronary spasm provocation tests using acetylcholine or ergonovine. The results of the provocation tests revealed that 59 patients had vasospastic angina (VSA), and that 80 did not (non-VSA). We analyzed the association between VSA and renal dysfunction using the estimated glomerular filtration rate (eGFR). The eGFR was significantly lower in the VSA group than in the non-VSA group (P=0.013). The patients were assigned to quartiles (Q) 1, 2, 3 and 4 based on eGFR (ml·min-1·1.73 m2) <64.1, 64.1-74.7, 74.8-85.0 and ≥85.1, respectively, in each of which the prevalence of VSA was 57%, 53%, 34% and 26%, respectively. The prevalence of VSA was significantly higher in Q1 than in Q4 (P=0.008). Logistic regression analysis showed that the independent factors associated with the presence of VSA were a lower eGFR (P=0.011) and male gender (P=0.001). Conclusions: Lower levels of eGFR in our study population were significantly and independently associated with a high prevalence of VSA, suggesting that a lower eGFR could be a risk factor for VSA.
キーワード: Chronic kidney disease / Coronary spasm / Endothelial dysfunction
URI: http://hdl.handle.net/10069/25611
ISSN: 13469843
DOI: 10.1253/circj.CJ-10-0864
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25611



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