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An Ionic Polymer Bead-supported Lipid System Using Naturally Occurring Phospholipids

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タイトル: An Ionic Polymer Bead-supported Lipid System Using Naturally Occurring Phospholipids
著者: Osei-Asante, Samuel / Haratake, Mamoru / Fuchigami, Takeshi / Nakayama, Morio
発行日: 2010年 8月31日
出版者: SAGE Publications
引用: Journal of Bioactive and Compatible Polymers, 25(5), pp.455-464; 2010
抄録: Spherically supported bilayer membranes on cationic polymer beads were prepared from naturally occurring phospholipids (phosphatidylcholine (PC) and phosphatidylserine (PS)). The amount of phospholipids bound to the cationic polymer beads from the liposomal suspensions of various lipid compositions increased with increases in anionic PS. Confocal fluorescence microscopic observations with a fluorescence membrane probe indicated that the phospholipid molecules in the phospholipid-bead complexes were along the surface of the beads. Negatively charged trypan blue dye was preferably bound to the phospholipid-free beads by electrostatic attractive interaction, but was excluded from the phospholipid-bead complexes due to the bilayer membrane structure formed on the beads. This method could provide a better mimetic of biological membranes in comparison to physically unstable conventional liposomes.
キーワード: bilayer membrane / confocal fluorescence microscopy / phospholipid / polymer bead
URI: http://hdl.handle.net/10069/25641
ISSN: 08839115
DOI: 10.1177/0883911510371149
権利: © The Author(s), 2010.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25641



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