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The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population.

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タイトル: The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population.
著者: Matsuse, Michiko / Takahashi, Meiko / Mitsutake, Norisato / Nishihara, Eijun / Hirokawa, Mitsuyoshi / Kawaguchi, Takahisa / Rogounovitch, Tatiana / Saenko, Vladimir / Bychkov, Andrey / Suzuki, Keiji / Matsuo, Keitaro / Tajima, Kazuo / Miyauchi, Akira / Yamada, Ryo / Matsuda, Fumihiko / Yamashita, Shunichi
発行日: 2011年 9月
出版者: British Medical Association
引用: Journal of Medical Genetics, 48(9), pp.645-648; 2011
抄録: Background FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown. Objective We aim to examine the association of the two genes with Japanese sporadic PTC, which exhibits high BRAF(V600E) mutation rate. Methods 507 Japanese sporadic PTC cases and 2766 controls were genotyped for rs965513 (FOXE1) and rs944289 (NKX2-1). PTC cases were also examined for their BRAF(V600E) mutational status. Results The association of both rs965513 (p=1.27×10(-4), OR=1.69, 95% CI 1.29 to 2.21) and rs944289 (p=0.0121, OR=1.21, 95% CI 1.04 to 1.39) with the risk of sporadic PTC was confirmed. Subgroup analysis based on the BRAF mutational status showed strong association of rs965513 with BRAF(V600E)-positive cases (p=2.26×10(-4), OR=1.72, 95% CI 1.29 to 2.29), but not with BRAF(V600E)-negative cases (p=0.143, OR=1.52, 95% CI 0.87 to 2.65). However, there was no difference in the observed effect size between both subgroups. For rs944289, both subgroups showed marginal association (p=0.0585, OR=1.17, 95% CI 0.99 to 1.37 for BRAF(V600E)-positive cases; p=0.0492, OR=1.35, 95% CI 1.00 to 1.81 for BRAF(V600E)-negative cases). Conclusions Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC. No clear associations were observed for either SNP with BRAF(V600E) status.
キーワード: FOXE1 / NKX2-1 / papillary thyroid carcinoma / genotyping / SNP
URI: http://hdl.handle.net/10069/25665
ISSN: 00222593
DOI: 10.1136/jmedgenet-2011-100063
PubMed ID: 21730105
権利: Copyright Article author (or their employer) 2011.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/25665



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