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In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.

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Title: In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.
Authors: Morinaga, Yoshitomo / Yanagihara, Katsunori / Araki, Nobuko / Yamada, Koichi / Seki, Masafumi / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yamada, Yasuaki / Kohno, Shigeru / Kamihira, Shimeru
Issue Date: Oct-2010
Publisher: Informa Healthcare USA, Inc.
Citation: Experimental lung research, 36(8), pp.484-490; 2010
Abstract: It is important to regulate excessive inflammation when patients with severe infectious disease are treated. Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. The combination therapy did not show a significant survival improvement compared to the treatment with fluoroquinolone alone, but reduced bacteria number and inflammatory cells in the early phase. The combination therapy can contribute to treatment of L. pneumophila pneumonia with protecting lungs.
Keywords: Legionella pneumophila / neutrophil elastase severe pneumonia
URI: http://hdl.handle.net/10069/25920
ISSN: 01902148
DOI: 10.3109/01902141003728874
PubMed ID: 20939755
Rights: © 2010 Informa Healthcare USA, Inc. / This is an electronic version of an article published in Experimental lung research, 36(8), pp.484-490; 2010. Experimental lung research is available online at: http://www.informaworld.com/openurl?genre=article&id=doi:10.3109/01902141003728874.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/25920

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