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Transfer profile of intramuscularly administered tetrodotoxin to artificial hybrid specimens of pufferfish, Takifugu rubripes and Takifugu niphobles.


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Title: Transfer profile of intramuscularly administered tetrodotoxin to artificial hybrid specimens of pufferfish, Takifugu rubripes and Takifugu niphobles.
Authors: Wang, Junjie / Araki, Taiichiro / Tatsuno, Ryohei / Nina, Shinya / Ikeda, Koichi / Hamasaki, Masaomi / Sakakura, Yoshitaka / Takatani, Tomohiro / Arakawa, Osamu
Issue Date: Nov-2011
Publisher: Elsevier
Citation: Toxicon, 58(6-7), pp.565-569; 2011
Abstract: Tetrodotoxin (TTX) was intramuscularly administered to artificially hybridized specimens of the pufferfish Takifugu rubripes and Takifugu niphobles to investigate toxin accumulation in hybrids, and TTX transfer/accumulation profiles in the pufferfish body. In the test fish administered 146 MU TTX in physiologic saline, TTX rapidly transferred from the muscle via the blood to other organs. Toxin transfer to the ovary rapidly increased to 53.5 MU/g tissue at the end of the 72-h test period. The TTX content in the liver and skin was, at most, around 4-6 MU/g tissue, and in the testis it was less than 0.01 MU/g tissue. On the other hand, based on the total amount of toxin per individual (% of the administered toxin), the skin and the liver contained higher amounts (20-54% and 2-24%, respectively), but the amount in the liver rapidly decreased after 8-12 h, and fell below the level in the ovary after 48 h. These findings suggest that part of the TTX is first taken up in the liver and then transferred/accumulated in the skin in male specimens and in the ovary in female specimens.
Keywords: Hybrid / Intramuscular administration / Pufferfish / Takifugu niphobles / Takifugu rubripes / Tetrodotoxin
URI: http://hdl.handle.net/10069/26257
ISSN: 00410101
DOI: 10.1016/j.toxicon.2011.08.019
PubMed ID: 21920378
Rights: Copyright © 2011 Elsevier Ltd. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/26257

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