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Ezetimibe and vascular endothelial function.


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Title: Ezetimibe and vascular endothelial function.
Authors: Ikeda, Satoshi / Maemura, Koji
Issue Date: Jan-2011
Publisher: Bentham Science Publishers
Citation: Current Vascular Pharmacology, 9(1), pp.87-98; 2011
Abstract: Hypercholesterolemia is a major risk factor for cardiovascular diseases that has been managed mostly with 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitors (statins) that suppress de novo cholesterol synthesis in the liver. Statins also have beneficial pleiotropic effects on the atherosclerotic process that are independent of their ability to lower lipid values. However, the levels of low-density lipoprotein cholesterol (LDL-C) in most hypercholesterolemic patients at high risk for cardiovascular disease do not reach the goals proposed by guidelines even when prescribed with statins. Ezetimibe is a new lipid-lowering agent that blocks the intestinal absorption of dietary and biliary cholesterol and reduces LDL-C levels, especially when combined with statins. However, its effect on cardiovascular events remains unknown. We reviewed the effects of ezetimibe on cardiovascular diseases, in particular, vascular endothelial function, which is initially impaired during the atherogenetic process and is an important predictor of cardiovascular events. The simultaneous inhibition of cholesterol synthesis by statin and of cholesterol absorption by ezetimibe might retard the atherogenetic process. These effects are considered to be mainly mediated by lipid lowering. However, further studies should elucidate the mechanism of the anti-atherosclerotic effects induced by ezetimibe; for instance, whether or not it directly affects atherogenesis independently from its lipid-lowering effects.
Keywords: Atherosclerosis / C-reactive protein / Cardiovascular disease / Nitric oxide / Oxidative stress
URI: http://hdl.handle.net/10069/26388
ISSN: 15701611
PubMed ID: 21044017
Rights: © 2011 Bentham Science Publishers Ltd.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/26388

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