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Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.

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タイトル: Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.
著者: Ishibashi, Daisuke / Yamanaka, Hitoki / Mori, Tsuyoshi / Yamaguchi, Naohiro / Yamaguchi, Yoshitaka / Nishida, Noriyuki / Sakaguchi, Suehiro
発行日: 2011年11月21日
出版者: Elsevier BV
引用: Vaccine, 29(50), pp.9321-9328; 2011
抄録: Prions, the causative agents of prion diseases, are immunologically tolerated because their major component, prion protein (PrP), is a host-encoded molecule. Therefore, no effective prion vaccines have been developed. We previously showed that heterologous bovine and sheep PrP immunizations of mice overcame tolerance by an antigenic mimicry mechanism to efficiently induce anti-PrP auto-antibodies (Abs), significantly prolonging incubation times in mice subsequently infected with the mouse-adapted Fukuoka-1 prion. These results prompted us to investigate if non-mammal derived molecules able to antigenically mimic anti-prion epitopes, could act as prion vaccines. We show here that immunization of mice with recombinant succinylarginine dihydrolase, a bacterial enzyme with a peptide sequence similar to an anti-prion epitope, induced anti-PrP auto-Abs with anti-prion activity and significantly retarded survival times of the mice subsequently infected with Fukuoka-1 prions. These results might open a way for development of a new type of antigenic mimicry-based prion vaccine.
キーワード: Antigenic mimicry / Humoral immunity / Prion / Vaccine
URI: http://hdl.handle.net/10069/26410
ISSN: 18732518 / 0264410X
DOI: 10.1016/j.vaccine.2011.10.017
PubMed ID: 22008817
権利: Copyright © 2011 Elsevier Ltd. All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/26410



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