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The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center


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Title: The outcomes of methicillin-resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center
Authors: Takatsuki, Mitsuhisa / Eguchi, Susumu / Yamanouchi, Kosho / Hidaka, Masaaki / Soyama, Akihiko / Miyazaki, Kensuke / Tajima, Yoshitsugu / Kanematsu, Takashi
Issue Date: Nov-2010
Publisher: 日本肝胆膵外科学会 / Japanese Society of Hepato-Biliary-Pancreatic Surgery
Citation: Journal of Hepato-Biliary-Pancreatic Sciences, 17(6), pp.839-843; 2010
Abstract: Objective: The objective of this study is to present results from our review of methicillin-resistant Staphylococcus aureus (MRSA) infection in living-donor liver transplant (LDLT) recipients. Methods: Seventy patients with primary LDLT between August 1997 and May 2007 were retrospectively reviewed. Results: Overall, 9 patients (12.9%) encountered various kinds of MRSA infection after transplantation [peritonitis (6), bacteremia (6), pneumonia (3), wound infection (3), cholangitis (1)]; 4 of these 9 patients died. Of these 4 expired patients, 3 were highly urgent cases with very poor pretransplant status under ventilator support. In one patient, linezolid was effective after teicoplanin failure for severe systemic MRSA infections (bacteremia, peritonitis, cholangitis, pneumonia, and enteritis). Of the 4 patients in whom MRSA was isolated only in a nasal swab before transplantation, none developed MRSA infection after transplantation with a 3-day course of mupirocin prophylaxis. Conclusions: MRSA infection was a contributing factor in death after transplantation in cases with poor pretransplant status. Linezolid was effective even for treating systemic MRSA infection after LDLT. A short course of mupirocin prophylaxis seemed to be effective and did not have any adverse effects.
Keywords: Liver transplantation / Living donor / Methicillin-resistant Staphylococcus aureus
URI: http://hdl.handle.net/10069/26614
ISSN: 18686974
DOI: 10.1007/s00534-010-0273-5
Rights: © Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer 2010
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/26614

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