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薬剤耐性菌を中心に


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Title: 薬剤耐性菌を中心に
Other Titles: A view on antibiotic-resistant bacteria
Authors: 平泻, 洋一
Authors (alternative): Hirakata, Yoichi
Issue Date: Jul-2003
Publisher: 日本化学療法学会 / Japanese Society of Chemotherapy
Citation: 日本化学療法学会雑誌, 51(7), pp.431-434; 2003
Abstract: 難治性尿路感染症の成立要因には,基礎疾患,体内挿入物とそれに伴うbiofilm の形成などに加え,原因菌の薬剤耐性の問題が挙げられる。特に本来耐性傾向の強い緑膿菌が,抗緑膿菌製剤に耐性を獲得し多剤耐性化した場合,現存の抗菌薬はすべて無効である。その原因のひとつに,メタロβ.ラクタマーゼ産生が挙げられる。多剤耐性緑膿菌やニューキノロン耐性菌は,泌尿器科領域のみならず全領域で重要な耐性菌で今後さらに問題となる可能性が高い。分子レベルでの薬剤耐性機構が明らかとなっている今日では,抗菌薬の開発と同時に耐性機構の阻害薬の開発も望まれる。 / In intractable urinary tract infections,antibiotic.resistant bacteria play an important role in addition to the underlying diseases,medical devices such as urinary tract catheters,and biofilm formation. Multidrug. resistant(MDR)Pseudomonas aeruginosa resistant to carbapenem,aminoglycoside,and new quinolon commonly used as antipseudomonal antibiotics cannot be treated successfully with existing antibiotics. Production of metallo.β.lactamases is onemechanism in MDR of P. aeruginosa.MDR P. aeruginosa and fluoroquinole.resistant bacteria are clinical concerns in urology and all other medical fields. Since the molecular mechanisms in antibiotic resistance have been identified,resistance inhibitors are in urgent need of development,as well as new antibiotics.
Keywords: 尿路感染症 / 薬剤耐性菌 / メタロβ–ラクタマーゼ産生菌 / キノロン耐性菌
URI: http://hdl.handle.net/10069/26663
ISSN: 13407007
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/26663

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