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Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.


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Title: Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan.
Authors: Eguchi, Susumu / Soyama, Akihiko / Hidaka, Masaaki / Takatsuki, Mitsuhisa / Muraoka, Izumi / Tomonaga, Tetsuo / Kanematsu, Takashi
Issue Date: Oct-2011
Publisher: Springer Verlag
Citation: Surgery Today, 41(10), pp.1325-1331; 2011
Abstract: Liver transplantation for patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) remains challenging. The advent of highly active antiretroviral therapy (HAART) for HIV has reduced mortality from opportunistic infection related to acquired immunodeficiency syndrome dramatically, while about 50% of patients die of end-stage liver cirrhosis resulting from HCV. In Japan, liver cirrhosis frequently develops after HCV-HIV coinfection resulting from previously transfused infected blood products for hemophilia. The problems of liver transplantation for those patients arise from the need to control calcineurin inhibitor with HAART drugs, the difficulty of using interferon after liver transplantation with HAART, and the need to control intraoperative coagulopathy associated with hemophilia. We review published reports of liver transplantation for these patients in the updated world literature.
Keywords: Coinfection / Hepatitis C virus / Highly active antiretroviral therapy / Human immunodeficiency virus / Liver transplantation
URI: http://hdl.handle.net/10069/26865
ISSN: 09411291
DOI: 10.1007/s00595-010-4556-x
PubMed ID: 21922353
Rights: © Springer 2011. / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/26865

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